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Marini J.J.

Professor of Medicine
University of Minnesota

University: Johns Hopkins School of Engineering (highest graduating honors, 1969)

Undergraduate medical education was received at Johns Hopkins University School of Medicine in Baltimore, Maryland (USA) 1969-1973. Postgraduate Residency, Chief Residency in Internal Medicine, and Fellowship Training in Pulmonary Medicine were taken at the University of Washington, Seattle 1973-1978. Associate Professor of Medicine at the University of Washington in July, 1983. Tenured Associate Professor of Medicine at Vanderbilt University 1983-1988. Professor of Medicine, University of Minnesota (1989-Present), and Division Director of Pulmonary and Intensive Care Medicine at Regions Hospital (St. Paul) 1989-1999.

Currently: Professor of Medicine, University of Minnesota and Director of Physiological & Translational Research, Regions Hospital, St. Paul, Minnesota.

Dr. Marini is presently a member of numerous editorial boards, an author and editor of 7 medical textbooks, and contributor of more than 250 scientific and educational articles. “Critical Care Medicine—The Essentials”, a text that has been translated into 5 languages, is now in its 4th edition.

Young Medal--the highest award given by the American Association for Respiratory Care (AARC)--in 1998.

2011 Recipient of the Distinguished Achievement Award of the American Thoracic Society (ATS), the scientific branch of the American Lung Association.

2015 Recipient of annual SMART Award>

Dr. Marini’s investigative work has always concentrated in understanding the cardiopulmonary physiology and management of acute respiratory failure, with an emphasis on patient-ventilator interactions which occur in critical illness. In the majority of that research, he has positioned himself at the interface between basic physiology and clinical medicine so as to develop mechanistic insights that advance clinical practice.

General areas of investigation have included cardio-pulmonary interactions; dynamic hyperinflation; mathematical modeling of respiratory mechanics; patient-ventilator interactions; work-of-breathing during mechanical ventilation; tracheal gas insufflation; and, most recently, airway bio-fluids, propagation of lung injury, chest mechanics of uni-lateral lung disease, cardiovascular effects of high dose insulin, and the cellular pathobiology of ventilator-induced lung injury. Investigative methods have ranged from mathematical models of invasive and non-invasive mechanical ventilation and gas exchange through bench testing, to laboratory investigation using small and large animal models of lung injury and therapeutic practices. Bedside observation, physiological investigations and observational studies have provided data of direct interest to clinicians as well as seeded questions for exploration in the laboratory setting. Investigations into the pathophysiology of ventilator induced lung injury, intra-abdominal pressure, pleural effusion, asymmetrical lung mechanics and airway secretion mobilization are representative of this two-way interchange. Currently he collaborates with colleagues who are well versed in advanced imaging and biological sciences to explore questions of mutual interest.

Outside the bench lab setting, he has engaged in physiologic investigations involving normal subjects and patients with both acute and chronic respiratory illnesses. Still an active clinician and educator, Dr. Marini has helped develop techniques for improving our diagnostic ability at the bedside (e.g., in monitoring and weaning assessment) as well as for implementing therapeutic techniques of value to the care of the critically ill patient. His initial description of auto-PEEP and work of breathing in the ventilated patient have helped launch an entire field of applied respiratory physiology.